Fu-Sen Liang

Assistant Professor

Other Information

Degree: PhD, The Scripps Research Institute


Chemical Biology, Biochemistry, Organic, Pharmaceutical



  • B.S. Chemistry, 1994, National Taiwan University, Taiwan
  • M.S. Chemistry, 1996, National Chiao Tung University, Taiwan
  • Ph.D. Chemistry, 2005, The Scripps Research Institute, La Jolla, CA
  • Postdoctoral fellow, 2005-2011, Stanford University School of Medicine, Stanford, CA



Our group works at the interface of chemistry and biology. We are particularly interested in developing novel interdisciplinary research tools that utilize the strategy of controlled proximity to temporally and spatially control the levels and/or activities of specific cellular molecules in order to investigate or manipulate biological processes. Our goals are to be able to:

  1. Modulate activities of endogenous microRNAs.
  2. Monitor and regulate cellular proteins by small molecule-probes.
  3. Control local protein synthesis.

Using these unique technologies along with multidisciplinary approaches, we would like to answer important questions in neuroscience and cancer biology, and develop novel therapies for related human diseases.

Selected Publications

  • Liang, F. -S., Ho, W. Q. & Crabtree, G. R. “Engineering the ABA Plant Stress Pathway for Regulation of Induced Proximity” Science Signaling20114, rs2.
  • Liang, F. -S., Greenberg, W. A.; Hammond, J. A., Hoffmann, J, Head, S. R. & Wong, C. -H. “Evaluation of RNA Binding Specificity of Aminoglycosides with DNA Microarrays” Proc. Natl. Acad. Sci. U.S.A.2006103, 12311.
  • Liang, F. -S., Brik, A., Lin, Y.-C., Elder, J. H. & Wong, C. -H. “Epoxide Opening in Water for Rapid Inhibitor Discovery in Microtiter Plate and in situ Screening” Bioorg. Med. Chem.200614, 1058.
  • Liang, F. -S., Wang, S.-K., Nakatani, T. & Wong, C. -H. “Targeting RNAs by Tobramycin Analogs” Angew. Chem. Int. Ed.200443, 6496.