Organic Chemistry, Chemical Biology, Genetically-Encoded Natural Products, Microbial Genetics, Bioinformatics, Metabolic Pathways, Drug Discovery
- Bachelor of Science (BSc): Madras University (The New College), Chennai, India, 1994 – 1997.
- Master of Science (MSc): Indian Institute of Technology, Kanpur, India, 1997 – 1999.
- PhD Indiana University, Bloomington, 1999 – 2005.
- Post-Doctoral Research, University of Utah, 2005 – 2008.
Teaching at Case Western Reserve University
|Spring 2010||Advanced Organic Chemistry II (CHEM 422)|
|Fall 2010||Synthetic Methods in Organic Chemistry (CHEM 435)|
|Fall 2011||Introductory Organic Chemistry Laboratory I (CHEM 233)|
|Spring 2012||Introductory Organic Chemistry Laboratory II (CHEM 234)|
|Fall 2012||Synthetic Methods in Organic Chemistry (CHEM 435)|
|Spring 2013||Introductory Organic Chemistry Laboratory I (CHEM 233)|
|Spring 2014||Introductory Organic Chemistry Laboratory I (CHEM 233)|
|Fall 2014||Organic Chemistry I (CHEM 323)|
|Spring 2015||Introductory Organic Chemistry Laboratory I (CHEM 233)|
Research in the Viswanathan Group
The Viswanathan laboratory’s contributions to the fields of bio-organic chemistry and natural product biosynthesis are focused on building two synergistic platforms: a. developing understanding of nature’s molecular construction processes and b. discovery of new biocatalytic systems. These goals rest on four fundamental disciplines we study, namely: Organic Chemistry, Microbiology, Natural Products and Biocatalysts. For a visual representation, see cartoon below. Using tools such as genomics, asymmetric synthesis, mechanistic enzymology, and microbiology we design platforms that delineate bio-organic mechanisms of enzyme-catalyzed processes. As an application of our research strategies, we develop novel antivirulent therapeutics against infectious diseases, design and construct bio-sensors to detect disease-relevant metabolites, and modulate human enzymes involved in cancer pathways.
Selected Recent Publications
- Dana M. Bis, Yang H. Ban, Elle D. James, Norah Alqahtani, Rajesh Viswanathan, and Amy L. Lane* “Characterization of the Nocardiopsin Biosynthetic Gene Cluster Reveals Similarities and Differences to the Rapamycin and FK-506 Pathways” ChemBioChem, 2015, Just Accepted.
- Karthikeyan Thandavamurthy, Deepti Sharma, Suheel K. Porwal, Dale Ray and Rajesh Viswanathan* “Regioselective Cope Rearrangement and Prenyltransfers on Indole Scaffold Mimicking Fungal and Bacterial Dimethyl Allyl Tryptophan Synthases” J. Org. Chem., 2014, 79, 10049–10067. DOI: 10.1021/jo501651z
- Melinda L. Micallef*, Deepti Sharma*, Brittney M. Bunn, Lena Gerwick, Rajesh Viswanathan§, Michelle C. Moffitt§ “Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria” BMC Microbiology 2014, 14:213, DOI: 10.1186/s12866-014-0213-7
- David Kuo, Guanping Yu, Wyatt Hoch, Lisa Long, Mahmoud Ghannoum, Nancy Nagy, Clifford V. Harding, Rajesh Viswanathan, and Menachem Shoham* “Novel quorum-quenching agents promote MRSA wound healing and sensitize MRSA to b-lactam antibiotics” Antimicrobial Agents and Chemotherapy, Just Accepted. DOI: 10.1128/AAC.04767-14
- Liu, Z.; Reba, S.; Chen, W-D.; Boom, W. H.; Porwal, S. K.; Viswanathan, R.; and Devireddy, L.*“Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection.” J. Exp. Med. 2014, 211, 1197-1213. Published May 26, 2014, DOI: 10.1084/jem.20132629.
- Porwal, S. K.; Furia, E.; Harris, M. E.; Viswanathan, R.*; and Devireddy, L.* “Synthetic, Potentiometric and Spectroscopic Studies of Chelation between Fe(III) and 2, 5-DHBA Supports Salicylate-Mode of Siderophore Binding Interactions.” J. Inorg. Biochem. Just Accepted. DOI: 10.1016/j.jinorgbio.2014.12.010
- Yu, G.; Kuo, D.; Shoham, M. and Viswanathan, R.* “Synthesis and in vitro Evaluation of a Biaryl Hydroxyketone Library as Antivirulence Agents against MRSA.” ACS Comb. Sci. 2014, 16, 85–91. DOI: 10.1021/co400142t
- Voelker, A. E. and Viswanathan, R.* “Synthesis of a Suite of Bioorthogonal GST Substrates and Their Enzymatic Incorporation for Protein Immobilization” J. Org. Chem. 2013, 78, 9647-9658. DOI: 10.1021/jo401278x
- Voelker, A. E. and Viswanathan, R. “Self-Catalyzed Immobilization of GST-Fusion Proteins for Genome-Encoded Biochips” Bioconjugate Chem., 2013, 24, 1295-1301. DOI: 10.1021/bc400128g
* corresponding author