Frank Hovorka Assistant Professor in Chemistry
Scientific Oversight Board Member, Small Molecule Drug Discovery Core (SMDDC)
Natural Product Synthesis, Mechanism, Genetically-Encoded Biosynthetic Pathways, Drug Discovery
- Bachelor of Science (BSc): Madras University (The New College), Chennai, India, 1994 – 1997.
- Master of Science (MSc): Indian Institute of Technology, Kanpur, India, 1997 – 1999.
- PhD Indiana University, Bloomington, 1999 – 2005.
- Post-Doctoral Research, University of Utah, 2005 – 2008.
Research in the Viswanathan Group
Basic chemical questions and applied biological problems form two facets of our scientific endeavor. Our basic science is focused on: a. biomimetic synthesis of natural products and b. understanding the mechanisms underlying biosynthesis and metabolism. Applied biological problems involve development of small-molecule based therapeutic strategies for combating antibiotic resistance and proliferative diseases such as cancer. In a collaborative setup, we routinely employ asymmetric synthesis, genomics, mechanistic enzymology, and microbiology as tools to experimentally test bioorganic concepts.
These goals rest on four fundamental disciplines we study, namely: Organic Chemistry, Microbiology, Natural Products and Biocatalysts, as represented visually below.
Selected Recent Publications
- Norah Alqahtani‡, Suheel K Porwal‡, Elle D James, Dana Bis, Jonathan A Karty, Amy L. Lane* and Rajesh Viswanathan* “Synergism between Genome Sequencing, Tandem Mass Spectrometry and Bio-Inspired Synthesis Reveals Insights into Nocardioazine B Biogenesis” Organic & Biomolecular Chemistry, 2015, 13, 7177 – 7192. ‡ – contributed equally. Click here.
- Elle D. James, Bryan A. Knuckley, Norah Alqahtani, Suheel Porwal, Jonathan A. Karty, Rajesh Viswanathan,* and Amy L. Lane* “Two distinct cyclodipeptide synthases from a marine actinomycete catalyze biosynthesis of the same diketopiperazine natural product”. ACS Synthetic Biology, Article ASAP Accepted: December 9 2015. Click here.
- Karthikeyan Thandavamurthy, Deepti Sharma, Suheel K. Porwal, Dale Ray and Rajesh Viswanathan* “Regioselective Cope Rearrangement and Prenyltransfers on Indole Scaffold Mimicking Fungal and Bacterial Dimethyl Allyl Tryptophan Synthases” J. Org. Chem. 2014, 79, 10049-10067. Click here.
- Melinda L. Micallef*, Deepti Sharma*, Brittney M. Bunn, Lena Gerwick, Rajesh Viswanathan§, Michelle C. Moffitt§ “Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria” BMC Microbiology 2014, 14:213
* – Equal contribution; § – Co-corresponding authorship. Click here.
- Melinda L. Micallef, Paul M. D’Agostino, Deepti Sharma, Rajesh Viswanathan, Michelle C. Moffitt* “Genome mining for natural product biosynthetic gene clusters in the subsection V cyanobacteria.” BMC Genomics, 2015, 16:669. Click here.
- Dana M. Bis, Yang H. Ban, Elle D. James, Norah Alqahtani, Rajesh Viswanathan, Amy L. Lane* “Characterization of the Nocardiopsin Biosynthetic Gene Cluster Reveals Similarities and Differences to the Rapamycin and FK-506 Pathways” ChemBioChem, 2015, 16, 990-997. Click here.
- Yu, G.; Kuo, D.; Shoham, M. and Viswanathan, R.* “Synthesis and in vitro Evaluation of a Biaryl Hydroxyketone Library as Antivirulence Agents against MRSA.” ACS Comb. Sci. 2014, 16, 85–91. Click here.
- Md. Faiz Ahmad, Sarah E Huff, John Pink, Intekhab Alam, Andrew Zhang, Kay Perry, Michael E. Harris, Tessianna Misko, Nancy Olenick, Suheel K. Porwal, Rajesh Viswanathan, and Chris Godfrey Dealwis* “Identification of non-nucleoside human ribonucleotide reductase modulators” J. Med. Chem. 2015, 58, 9498–9509. Click here.
- Voelker, A. E. and Viswanathan, R.* “Synthesis of a Suite of Bioorthogonal GST Substrates and Their Enzymatic Incorporation for Protein Immobilization” J. Org. Chem. 2013, 78, 9647-9658. Click here.
- Voelker, A. E. and Viswanathan, R.* “Self-Catalyzed Immobilization of GST-Fusion Proteins for Genome-Encoded Biochips” Bioconjugate Chem., 2013, 24, 1295-1301. Click here.
* corresponding author
Teaching at Case Western Reserve University
|Spring 2010||Advanced Organic Chemistry II (CHEM 422)|
|Fall 2010||Synthetic Methods in Organic Chemistry (CHEM 435)|
|Fall 2011||Introductory Organic Chemistry Laboratory I (CHEM 233)|
|Spring 2012||Introductory Organic Chemistry Laboratory II (CHEM 234)|
|Fall 2012||Synthetic Methods in Organic Chemistry (CHEM 435)|
|Spring 2013||Introductory Organic Chemistry Laboratory I (CHEM 233)|
|Spring 2014||Introductory Organic Chemistry Laboratory I (CHEM 233)|
|Fall 2014||Organic Chemistry I (CHEM 323)|
|Spring 2015||Introductory Organic Chemistry Laboratory I (CHEM 233)|
|Fall 2015||Synthetic Methods in Organic Chemistry (CHEM 435)|
|Spring 2016||Introductory Organic Chemistry Laboratory I (CHEM 233)|