Course	Credits	Description
CHEM 406: Chemical Kinetics	3	Theory and characterization of chemical rate processes. Recommended preparation: Two semesters of undergraduate physical chemistry.
CHEM 412: Advanced Inorganic Chemistry I	3	Chemistry of inorganic systems. Spectroscopy, magnetism, and stereochemistry of transition metal compounds. Recommended preparation: One semester of undergraduate inorganic chemistry and two semesters of undergraduate physical chemistry.
CHEM 414: Organometallic Reactions and Structures	3	Bonding, structure, and mechanistic aspects of organometallic chemistry and the relevance of organometallic species to chemical catalysis. Recommended preparation: One semester of undergraduate inorganic chemistry.
CHEM 421: Advanced Organic Chemistry I	3	Structure, bonding, and molecular orbital theory. Stereochemistry and conformational analysis. Reaction mechanisms. Aromaticity and aromatic substitution. Pericyclic reactions, orbital symmetry conservation, and free radical chemistry. Recommended preparation: Two semesters of undergraduate organic chemistry.
CHEM 422: Advanced Organic Chemistry II	3	Carbocations and carbanions. Nucleophilic and electrophilic aliphatic substitutions. Heterolytic addition and elimination reactions. Electrophilic, nucleophilic, and free radical aromatic substitutions. Carbonyl reactions. Oxidations, reductions, rearrangements.
CHEM 425: Physical Methods for Determining Organic Structure	3	Structure determination of organic compounds using mass spectrometry and modern instrumental techniques such as infrared, ultraviolet, visible, and nuclear magnetic resonance spectroscopy. Recommended preparation: Two semesters of undergraduate organic chemistry. Offered as CHEM 325 and CHEM 425.
CHEM 428: Introductory Biochemistry I	3	A survey of biochemistry with a strong emphasis on the chemical logic underlying metabolic pathways and the evolution of biomolecules. Cellular architecture. Amino acids and protein structure, purification, analysis, and synthesis. DNA, RNA, the flow of genetic information, and molecular biological technology. Enzyme kinetics, catalytic, and regulatory strategies. Sugars, complex carbohydrates, and glycoproteins. Lipids and cell membranes. Glycolysis, gluconeogenesis, carbon fixation through the “dark reactions” of photosynthesis, aerobic catabolism through the citric acid cycle, and glycogen metabolism. Biosynthesis and degradation of fatty acids, amino acids, and proteins. Offered as CHEM 328 and CHEM 428.
CHEM 429: Biochemistry II: Living Systems	3	A survey of biochemical systems exploring their molecular circuitry and architecture. Lipids, cell membranes, channels and pumps. Signal transduction and receptors. Glycolysis, gluconeogenesis, citric acid cycle, and glycogen metabolism. Redox processes, electron transport, and photosynthesis. Fatty acid and amino acid biosynthesis and degradation. Nucleotide, lipid, and steroid biosynthesis. Sensory and immune systems. Molecular motors. Offered as CHEM 329 and CHEM 429.
CHEM 431: Laboratory Methods in Inorganic Chemistry	3	Synthesis, separation techniques, physical properties, and analysis. Advanced techniques of chemical synthesis, leading the student to the preparation of interesting inorganic and organometallic compounds. Offered as: CHEM 331 and CHEM 431. Prereq: CHEM 322
CHEM 433: Medicinal Chemistry and Drug Development	3	This course provides an overview on how principles in chemistry and biology are integrated to facilitate drug development. Primary emphasis will be placed on the development of organic molecules as drugs and metabolic enzymes as drug targets. Subjects pertinent to the introduction of medicinal chemistry, evaluation of drug efficacies in vitro and in vivo, and drug metabolism will be covered. Offered as CHEM 333 and CHEM 433.
CHEM 435: Synthetic Methods in Organic Chemistry	3	Systematic consideration of reactions involving functional group transformations and carbon-carbon bond formations used in modern organic synthesis. Recommended preparation: Two semesters of undergraduate organic chemistry.
CHEM 436: Complex Molecular Synthesis	3	An advanced organic chemistry course providing students with an in-depth examination of the art of total synthesis drawing from both classical and recent examples. Recommended preparation: Two semesters of undergraduate organic chemistry.
CHEM 440: Solar Energy Conversion	3	This is a multidisciplinary course from a chemist’s point of view. This course teaches the background necessary to read and understand the scientific literature on solar energy conversion, and includes some basic device physics, materials chemistry and chemistry. Topics provide an overview of the field and includes: Global energy perspective, principles of photovoltaics, crystalline solar cells, thin-film solar cells, dye-sensitized solar cells, organic solar cells (with emphasis on polymer-based solar cells), photoelectrochemical cells and artificial photosynthesis for fuel production, and semiconductor nanostructures and quantum dots for solar energy conversion. The course includes three laboratories and a demo using state-of-the-art equipment, as well as presentations of recent research articles by the graduate students. It is recommended that students have experience with thermodynamics. The following CWRU courses would meet this expectation: CHEM 301, CHEM 335, ENGR 225 or PHYS 313. Offered as CHEM 340 and CHEM 440.
CHEM 441: Functional Nanomaterials	3	This course is designed to introduce important concepts on the fundamental physical and chemical properties of technologically important nanometer scale materials. The course will cover an overview of the scientific principles pertaining to new properties at the nanoscale; synthesis and characterization tools; and existing and emerging applications of nanomaterials. It will center on current research developments on major classes of functional nanomaterials, including plasmonic nanoparticles, quantum dots, nanomagnets, carbon nanotubes, nanocatalysts and hybrid inorganic/organic nanostructures. In addition an emphasis will be placed on understanding the broader societal, economical and environmental impact of the scientific and technological advances brought forward by nanotechnology.
CHEM 442: Computational Chemistry	3	Computation has become an essential component of nearly all disciplines of chemical research and beyond. Nowadays, the vast majority of computational work reported in the literature was performed by experimental chemists themselves, not theoretical chemists. This course will introduce modern computational methodologies from fundamental theory to best practices. Topics will include thermochemistry, molecular dynamics, and spectroscopy using density functional, coupled cluster, and multireference theories. Hands-on applications will be stressed. A small independent computational research project will be required (CHEM 442 only).
CHEM 445: Electrochemistry I	3	Electrochemical properties and processes of electrode/electrolyte interfaces. Fundamental background for work in corrosion, electrodeposition, industrial electrolysis, electro-organic synthesis, batteries, fuel cells, and photoelectrochemical energy conversion. Recommended preparation: One semester of undergraduate physical chemistry.
CHEM 446: Quantum Mechanics I	3	Introduction of quantization, measurement and the Schrodinger equation; angular momentum and states of molecules. Perturbation theory, spectroscopy and chemical bonding. Variational theory and calculations of molecular properties. Recommended preparation: Two semesters of undergraduate physical chemistry. Offered as CHEM 337 and CHEM 446.
CHEM 447: Modern Topics in Physical Chemistry	3	This offering seeks to survey topics of interest in current interest in physical chemistry including: photovoltaic systems, plasmonic and magnetic heating, low-dimensional systems, physical properties of polymers, ultrafast spectroscopy, single molecule imaging, and theoretical chemistry and catalysis.
CHEM 450: Molecular Spectroscopy	3	Translation, rotation, vibration, and electronic transitions of molecules. Prereq: CHEM 446.
CHEM 475: Protein Biophysics	3	This course focuses on in-depth understanding of the molecular biophysics of proteins. Structural, thermodynamic and kinetic aspects of protein function and structure-function relationships will be considered at the advanced conceptual level. The application of these theoretical frameworks will be illustrated with examples from the literature and integration of biophysical knowledge with description at the cellular and systems level. The format consists of lectures, problem sets, and student presentations. A special emphasis will be placed on discussion of original publications. Offered as BIOC 475, CHEM 475, PHOL 475, PHRM 475, and NEUR 475.
CHEM 491: Modern Chemistry for Innovation I	3	The first half of a two-semester sequence providing an understanding of chemistry as a basis for successfully launching new high-tech ventures. The course will examine physical limitations to present technologies and the use of chemistry to identify potential opportunities for new venture creation. The course will provide experience in using chemistry for both identification of incremental improvements and as the basis for alternative technologies. Case studies will be used to illustrate recent commercially successful (and unsuccessful) venture creation and will illustrate characteristics for success. Admission to this course requires consent of the department.
CHEM 493: Feasibility and Technology Analysis	3	This course provides the tools scientists need to determine whether a technology is ready for commercialization. These tools include (but are not limited to): financial analysis, market analysis, industry analysis, technology analysis, intellectual property protection, the entrepreneurial process and culture, an introduction to entrepreneurial strategy and new venture financing. Deliverables will include a technology feasibility analysis on a possible application in the student’s scientific area. Offered as BIOL 493, CHEM 493, and PHYS 493.
CHEM 502: Special Topics in Inorganic Chemistry	1-6	(Credit as arranged.) Lectures on advanced topics in inorganic chemistry by staff or visiting lecturers. Course title, content, and credit change from year to year.
CHEM 504: Special Topics in Organic Chemistry	1-6	(Credit as arranged.) Lectures on advanced topics in organic chemistry by staff or visiting lecturers. Course title, content, and credit change from year to year.
CHEM 506: Special Topics in Physical Chemistry	1-6	(Credit as arranged.) Lectures on advanced topics in physical chemistry by staff or visiting lecturers. Course title, content, and credit change from year to year.
CHEM 507, 508: Special Readings in Chemistry	1-6	Detailed study of a special topic in chemistry under the guidance of a faculty member. Maximum credit of 6 hours.
CHEM 509: Special Topics in Analytical Chemistry	1-6
CHEM 601: Research	1-18	(Credit as arranged) Special research in an area of chemistry under the guidance of a faculty member.
CHEM 605: Chemistry Colloquium Series	0	Course content provided by Thursday chemistry department colloquia (or Frontiers in Chemistry lectures). Discussion sessions review previous lectures and lay foundation for forthcoming lectures.
CHEM 701: Dissertation (Ph.D.)	1-9	(Credit as arranged.) Prereq: Predoctoral research consent or advanced to Ph.D. candidacy milestone.