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IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex

The Tolbert Lab, in collaboration with researchers from Duke University and Rutgers University, have identified a potential drug candidate against Enterovirus 71 (EV71), a pathogen with no FDA-approved drug or vaccine.  The compound of interest binds to the viral RNA which induces a conformational change that inhibits viral replication. This work...

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Gray Group publishes luminescent, electroactive boron complexes

In DOE-funded research, graduate student Matthew Chrzanowski and undergraduate student Stephanie Collins (now in the PhD program at UC-Berkley) in the laboratory of Thomas Gray, investigated 9-Borabicyclononane bipyridyl complexes that fluoresce in solution while also possessing multiple, reversible reductions.  The fundamental work studying boron-centered molecules opens opportunities to use...

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