Gray/Berdis Research on Ir(III) Based Metallonucleosides Published in Chemistry—A European Journal

The Gray group’s current research on developing suitable metallo-probe to track nucleoside transporters across the cell membrane was published in Chemistry—A European Journal (8th Oct, 2013). In collaboration with Berdis Lab at Cleveland State University, we report a new strategy where cyclometalated Ir(III) complexes are “clicked” to C-1 of 2-deoxy-D-ribose in place of canonical nucleobases. Initial studies implicate the hENT family of nucleoside transporters as responsible for binding and transport of these metal-loaded nucleosides.

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